الفهرس 
Evaluation of cognitive and behavioral functions in children of epileptic mothers
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Abstract
As a result of in utero exposure to antiepileptic drugs (AEDs), there is a great risk of congenital malformations as well as cognitive and behavioral functions affection in later childhood. We examined the effects of AEDs on cognitive development and behavioral characteristics among school age children born to women with epilepsy. 40 children born to 23 epileptic mothers with mean age 8.68 years +8.5 SD were studied. 40 healthy children born to 34 healthy mothers with matched age, sex and education level were recruited. All mothers underwent wechsler test to measure IQ. All children underwent stanford binet test (fourth version) to measure IQ, child behavior checklist to detect behavioral abnormalities. Children exposed to AEDs showed statistically significant difference in the verbal reasoning (P=0.006), visual reasoning (P=0.012) and total IQ (P=0.002) compared to those children born to healthy mothers. There were significant correlations between children total IQ and maternal total IQ, polytherapy and valproate intake (more with dose >800mg/day). While no statistical significant difference was found in behavioral domains between children of epileptic mothers and children of healthy mothers. Using multiple regression analysis, the most independent factor affecting children IQ was valproate use and maternal IQ. Valproate has a significant impact on children{u2019}s IQ exposed to it in utero therefore it should be used with caution or preferably not for most women of childbearing potential, also maternal IQ contributes to the child{u2019}s IQ