الفهرس 
Aim of the workOnly 14 pages are availabe for public view
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Abstract
Non-alcoholic fatty liver disease (NAFLD) is a common medical condition worldwide and its prevalence has increased notably in the past few years due to the increases in prevalence of obesity and metabolic syndrome. This disease includes a broad range of hepatic disorders from simple fat accumulation in hepatic cells (simple steatosis) to hepatic tissue inflammation and fibrosis (Steatohepatitis; NASH) and finally cirrhosis and even hepatocellular carcinoma.
Pentraxin-3 (PTX-3) (an acute-phase protein) is a member of the long pentraxin protein family. It has been reported that PTX-3 is significantly associated with obesity, metabolic syndrome and cardiovascular diseases. In this study, we aimed to investigate the clinical usefulness of plasma Pentraxin3 (PTX3) levels as anoval diagnostic marker for NAFLD.
This case control study was conducted at tertiary care hospital at El Menoufia University Hospitals from June 2019 till April 2021 and performed on a total of 70 adult patients with NAFLD, and 20 normal healthy persons.
The current study revealed that there was a significant difference between the studied groups regarding BMI and waist circumference (WC). Steatohepatitis group had significantly higher mean values of BMI than steatosis group and control group. Also, steatosis group had significantly higher mean values of BMI than controls. In addition, steatohepatitis group had significantly higher mean values of WC than the control group. Also, steatosis group had significantly higher mean values of WC than the control group.
As regards biochemical and hematological data, the current study results revealed that there were significant differences between the studied groups regarding ALT, AST, ALP, albumin, creatinine, cholesterol, TG, HDL and LDL.
Steatohepatitis group had significantly higher mean values of ALT, AST, ALP, creatinine and LDL than steatosis group. On the other hand,Steatohepatitis group had significantly lower mean values of albumin and HDL than steatosis group. Also, Steatohepatitis group had significantly higher mean values of ALT, AST, GGT, cholesterol, TG and LDL than the control group while the same group had significantly lower mean values of ALP, albumin and HDL than the control group.