الفهرس 
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Abstract
Sore throat becomes an important health issue with rising prevalence. It describes the sensation of throat irritation caused by inflammation and/or irritation of the oro and hypopharynx due to infectious and non-infectious factors. It is believed that 30% of sore throats are due to unclear causes, which include GERD, OSAHS, allergies and other environmental factors. GERD is the retrograde ascendance of gastric contents into the esophagus or further to adjacent organs causing varying degrees of symptoms and signs with or without tissue damage. LPR is usually associated with GERD. Since 1903, LPR is believed to be a cause of extra-esophageal manifestations like heartburn, chronic cough, chronic sore throat, reflux induced asthma and laryngitis. Treatment using a twice 20 mg daily dose PPI, was thought to relief reflux induced pahryingitis and consequently sore throat complain. The aim of this study was to compare endoscopic pharyngeal and laryngeal findings in patients complaining of chronic afebrile sore throat using rigid endoscopy with a mounted high resolution camera before and after the usage of 3 weeks course of proton pump inhibitors.. This prospective study was carried out on 50 consecutive patients aged over 18 years complaining of chronic afebrile sore throat attending outpatient clinic of ORL-HNS, Tanta University Hospitals. The study started from the 1st of November 2019 till end of October 2021. In this study, Candidates were examined using rigid endoscopy with a mounted high resolution camera, using a 0 degree lens introduced nasally for nasopharyngeal examination, thereafter, another 70 degrees 60 lens introduced orally under local anesthesia using Lidocaine Spray for oropharyngeal, hypopharyngeal and laryngeal examination. Re-examination and comparison of results was done after at least 3 weeks of continuous intake of twice daily dose of 20 mg Omperazole. A questionnaire was filled considering personal data, habits, medical history as well as symptoms and signs before and after treatment. All results were tabulated and analyzed from the collected pre-treatment and post-treatment data. Our results showed highly significant improvement of sore throat complaint after PPI treatment. As well as reduction of some associated symptoms and endoscopic signs. The overall study denoted that there is an evident role of gastric acidity and LPR in the prevalent complaint of chronic afebrile sore throat of unclear etiology, and that LPR is important in the differential diagnosis of such cases even in case of absence of GERD history or classical GERD symptoms. Thus, starting PPI in such cases can achieve good resolution of the complaint. More studies are needed to assess the effect of LPR pharyngeal and laryngeal mucosa on larger group of population with the cooperation of gastroenterologists to make a better plan of combined management on longer study duration.