الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
Diabetes, a chronic disease, is one of the most common metabolic diseases in humans. It is characterized by hyperglycemia resulting from defects in insulin secretion, insulin action or both. There are two main types of diabetes mellitus (DM). In type 1 DM, pancreas cannot produce insulin as immune cells destroy beta cells. This causes glucose increase in blood known as hyperglycemia. In type 2 DM, pancreas produces less insulin as beta cells are partially destroyed. Also, Insulin cannot bind to its receptor because of insulin receptor defect (Dean et al., 2004). To induce hyperglycemia in animal models, there are many chemical compounds used to destroy beta cells in pancreas. Streptozotocin (STZ) is a common hyperglycemic chemical agent. It is naturally occurring glucosamine-nitrosourea compound (Abeeleh et al., 2009). Hyperglycemia is the major cause of diabetic complications like neuropathy. Neuropathy refers to damage in the peripheral nervous system, the network that sends signals between central nervous system (CNS) and all other parts of the body. Neuropathic pain is a chronic condition which leads to persistent pain symptoms (Qadir et al., 2019). Chemical drugs and medicinal plants extracts could be used to treat diabetic neuropathic pain. Formononetin (FMNT) is one of these medicinal plant extracts, it is extracted from many plants (plants of family Fabaceae and leguminous plants). It has many different biological activities importantly antioxidant, anti-inflammatory and anti-cancer activity (Li et al., 2018).