الفهرس 
Periorbital dark circlesOnly 14 pages are availabe for public view
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Abstract
Background: Dark circles are a color difference between the palpebral
skin and the remaining facial skin. Platelet-Rich Plasma (PRP) may serve
as a source of different growth factors to reduce the pigmentation as in
infraorbital dark circle and melasma. Carboxytherapy is carbon dioxide
infusion into human tissue for therapeutic purposes.
Aim of the work: This study aimed to compare the clinical efficacy of
PRP and carboxytherapy in the treatment of periorbital dark circles
(PODC).
Patient and Methods: Split-face study with 23 patients with PODC
treated with PRP at the right side and carboxytherapy at the left side. All
cases were assessed by photos before and after treatment, patient,
physician satisfaction scoring and area of percentage of melanin in skin
biopsies.
Results: There was statistically significant difference with p-value < 0.05
between PRP and carboxytherapy regarding patient and physician
satisfaction. Most results reported good physician and patient satisfaction
about PRP and fair physician and patient satisfaction about
caboxytherapy treatment. The area percent of melanin in biopsies before
treatment has a median which was 11.1, while in biopsies after PRP
injections had lowered to 5.9 which indicated 46.6% improvement. While
after carboxytherapy, the median of melanin area percent in biopsies was
9.49; which indicated 14.3% improvement.
Conclusion: PRP is considered a moderately effective treatment for
PODC. While, caboxtherapy is considered a mildly effective. However,
further studies on larger scales are required.
Keywords:Periorbital dark circles -Platelet-Rich Plasma- Caboxytherapy.