الفهرس 
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Abstract
Philadelphia- negative myeloproliferative neoplasms (MPNs) are a group of clonaldisorders characterized by myeloid lineage expansion in the bone marrow and peripheralblood. Classic MPN subtypes include Polycythemia Vera (PV), Essential Thrombocythemia (ET), and Primary Myelofibrosis (PMF) share similar pathophysiology, bone marrow morphology and clinical course with similar complications as thrombosis and leukemic transformation.Thrombotic events in classic MPNs are the most significant cause of morbidity andmortality that negatively impact patients‘quality of life and life expectancy Many researchers have demonstrated that the risk of thrombosis in classic MPNs is caused by an overlap of genetic and clinical causes. Different theories such as platelet activation,platelet aggregation, neutrophil aggregation, high red blood cell mass, coagulation cascade imbalance, and endothelial cell dysfunction can explain thrombosis. Also, chronic inflammation in MPNs is a contributory cause to thrombotic complications considering the platelet– leukocyte interactions affecting the inflammatory process and thereby thrombotic events.Despite comprehensive advances in the understanding of the clinical and pathophysiological factors of thrombosis in classic MPNs, further advances are needed for the prediction and stratification of thrombotic tendency.