الفهرس 
Evaluation of the role of melatonin supplementation in management of children having atopic dermatitis. at dermatology out patient clinic at Aboreesh Hospital
CONTENTOnly 14 pages are availabe for public view
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Abstract
Background: Atopic dermatitis (AD) is a chronic, pruritic, inflammatory skin disease that affects up to 25% of children and 2 to 3% of adults. Poor sleep efficiency is common in children with AD. Disturbed sleep is frequently reported by the patients and their family and is a major factor leading to an impaired quality of life. Lower nocturnal melatonin secretion was significantly associated with sleep disturbance in the patients with AD., higher total serum IgE levels. Objectives: Evaluation of the effect melatonin supplementation on Atopic dermatitis scoring and severity of the disease. Evaluation of melatonin supplementation on sleep disorders with atopic dermatitis. Method: This study is randomized clinical trial used double blind placebo. Results:There was significant difference between pre and post regarding serum Melatonin and IGE except in blood level of melatonin in placebo group. As regard Serum level of melatonin become 14pg/ml while before study was 59 pg/ml. but at placebo group started 25.5pg/ml and become 17pg/ml. IGE showed significant difference in per and post study .as it was 132 before melatonin and become 24 after supplementation of melatonin while in placebo group IGE DROP from 129 to 27. There was significant improvement in total eczema score in post study markedly from 69 to 2 in Melatonin group and from 72 to 3 in Placebo group. Conclusion: Melatonin supplementation is a safe and effective way to improve the sleep-onset latency and disease severity in children with AD.Inconsistent results have been reported in relation to the use of melatonin as a modulator in the atopic dermatitis. Studies conducted were limited so further studies are needed