الفهرس 
Oxidative stress biomarkers as risk factors for diabetic foot
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Abstract
Background : Ulceration of the foot is one of the major health problems for people with diabetes mellitus. Diabetes is the leading cause of amputation worldwide. characterization of risk factors that could prevent foot ulcers and amputations are not well established. Determination of biomarkers for early detection not only of foot ulcers but also nerve damage, infection and gangrene should be investigated. Because several studies have described the role of oxidative stress in causing diabetic foot ulcers, the evaluation of blood parameters of oxidative stress as biomarkers of diabetic foot risk must be considered. Aim of work: The aim of this study is to determine whether plasma levels of carbonylated proteins and total antioxidant capacity (TAC) could be suitable biomarkers of risk factors for diabetic foot.Subjects and methods: Cross sectional study included 30 type 2 diabetics with normal foot and 30 type 2 diabetic patients with diabetic foot compared to 20 of healthy control. All patients were subjected to: Full history taking and thorough clinical examination stressing on foot examination, measurement of BMI, & waist circumference. Biochemical tests including; FBS, 2h PPBS, HBA1c, Lipid profile & Albumin/creatinine ratio. Plasma levels of Protein carbonyl and total antioxidant capacity (TAC) were measured. Colored Doppler study was done for assessment of the tibial arteries. Together with measurement of Ankle-brachial and Toe-brachial arteries.Results: The diabetic foot group showed higher carbonylated protein levels and lower levels of TAC compared with the normal foot group. Conclusion: Therefore, the plasma levels of TAC and carbonyl proteins could provide additional information about the risk of diabetic foot