الفهرس 
A comparative study of phenylephrine and norepinephrine infusion in prevention of postspinal hypotension during spinal anesthesia in non-obstetric procedures
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Abstract
Background: Phenylepherine is established as a preferred vasopressor for maintaining blood pressure during spinal anesthesia; however, its use is associated with a reflex decrease in heart rate and an associated decrease in cardiac output. As a result, this has encouraged the investigation of alternative agents such as norepinephrine. Norepinephrine has weak Ý-adrenergic receptor agonist activity in addition to potent Ü-adrenergic receptor activity and therefore may be suitable for maintaining blood pressure with less negative effects on heart rate and cardiac output compared with phenylephrine. Methods: In a randomized, double-blinded study, 38 healthy patients undergoing lower abdominal incision surgical interventions under spinal anaesthesia were randomized to maintain intraoperative hemodynamics with infusion of norepinephrine 4 og/ml or phenylephrine 100 og/ml. This study compared between both groups to detect lowest mean arterial pressure during the first 10 minutes after spinal anesthesia. Heart rate, cardiac output, stroke volume and index of cardiac output number using electrical cardiometry were also compared. Results: The results of the study demonstrated that prophylactic phenylephrine infusion showed higher systolic blood pressure, diastolic blood pressure and mean arterial pressure than prophylactic norepinephrine infusion, although norepinephrine infusion showed higher heart rate readings compared to prophylactic phenylepherine infusion