الفهرس 
Analytical study of selected anti-Inflammatory drugs
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Abstract
Four simple, accurate, sensitive and economic attenuated total reflectance-fourier transform Infrared spectroscopic (ATR-FTIR) methods have been developed for the quantitative estimation of some non-steroidal anti-inflammatory drugs alone or in presence of related substances. The first method involves the determination of etodolac by direct measurement of the absorbance at 1716 cm⁻¹. In the second method, the second derivative of the IR spectra of tolfenamic acid and its imperity (2-chlorobenzoic acid) was used and the amplitudes were measured at 1084.27 cm⁻¹ and 1058.02 cm⁻¹ for tolfenamic acid and 2-chlorobenzoic acid, respectively. The third method used the first derivative of the IR spectra of bumadizone and its reported degradation product, N,N-diphenylhydrazine and the amplitudes were measured at 2874.98 cm⁻¹ and 2160.32 cm⁻¹ for bumadizone and N,N-diphenylhydrazine, respectively. The fourth method depends on measuring the amplitude of diacerein at 1059.18 cm⁻¹ and of rhein, its reported degradation product, at 1079.32 cm⁻¹ in their first derivative spectra. The four methods were successfully applied on the pharmaceutical formulations by extracting the active constituent in chloroform and the extract was directly measured in liquid phase mode using a specific cell. Moreover, validation of these methods was carried out following International conference of harmonisation (ICH) guidelines