الفهرس 
Role of serum zinc in the pathogenesis of febrile seizures in children
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Abstract
Febrile seizure (FS) is a common neurological disorder among children, which has been observed in 2{u2013}5% of all children. (Abbaskhaniyan et al., 2012). Pathophysiology of febrile seizure remains unknown, but genetic factors or electrolyte disturbance may have a role in its occurrence or recurrence (Heydarian et al., 2009). Several factors are involved in the etiology of febrile seizure (FS), among them is zinc (Zn) (Nasehi et al., 2015). Zinc provides structural stability for a variety of transcription factors. Zinc plays key roles in enzymatic activity, cell signaling and the modulation of neurotransmitter activity (Gower-Winter and Levenson, 2012). The aim of this study was to detect mean serum zinc level in each of the four groups of the studied children, correlate between zinc level on one side and febrile seizures (simple and complex) and idiopathic epilepsy on the other side. This study is a cross sectional case control study carried out on 160 children categorized into four groups, simple febrile seizures (FS) (40 patients), complex febrile seizures (40 patients) and idiopathic epilepsy (40 patients) who presented to Neurology Clinic of the Children Hospital - Cairo University and a control group randomly selected from normal children (who never had seizures) attending the general clinic over a period of twenty months from December, 2015 to July, 2017. Patients included in this study were subjected to detailed medical history, general and neurologic examination to categorize them into specific groups. Then, blood samples were withdrawn for serum zinc level detection by atomic absorption spectrophotometry. Then, results were statistically analyzed. In this study, there was a high statistically significant difference in the percentage of patients with normal and low serum zinc level among the three case groups with complex FS group having the highest percentage of patients with low serum zinc level