الفهرس 
Histological study on effect of curcumin versus aftamed on glucocorticoid induced skin atrophy and subsequent skin abrasions in male rats
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Abstract
This study aimed to evaluate the possible therapeutic effects of curcumin versus aftamed gel on glucocorticoid-induced skin atrophy, as well as on the subsequently induced abrasion wounds. Forty two adult male albino rats were divided into 4 groups: Group1 (Control group) of 6 rats. group II (steroid-exposed Group) of 12 rats subdivided equally into two subgroups IIA (subjected to clobetasol propionate cream) and IIB (subsequently exposed to skin abrasion). group III (curcumin-treated Group) of 12 rats were subdivided equally into two subgroups IIIA and IIIB. group IV (Aftamed-treated group) of 12 rats subdivided equally into two subgroups IVA and IVB. Skin biopsies were taken from the dorsum of rats 12th days from the stoppage of clobetasol propionate application. Sections were stained with hematoxylin and eosin, Masson’s trichrome and immunohistochemichal stain for PCNA and CK19. Epidermal thicknesses, mean area percent of collagen fibers and mean number of PCNA and CK19 immunopositive cells were measured. Steroid-exposed group showed thinning of epidermal and dermal layers with marked decrease in numbers of hair follicles and sebaceous glands with delay in wound healing. Increased epidermal thickness and reorganized dermal structural elements with increased PCNA and CK19 immunopositive cells are more obvious in curcumin than aftamed treated group. These findings suggest that topical application of curcumin had more improving effect on skin and its abrasions rather than aftamed gel