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Abstract In Yemen about 1.7% of the population is infected with chronic hepatitis C (Lavanchy 2011). Antibodies to hepatitis C (anti-HCV) were found in 2.1% healthy individuals and 21.5% of patients with chronic liver disease (el Guneid et al. 1993). A study in Hajjah governorate showed that the prevalence of HCV in blood donors was 1.1% (Haidar 2002). Soqotra an isolated big island in Yemen represent the highest prevalence for HCV antibodies, this may be due to a decreased health resource and education in that rural area. Sanaa surveys also represented higher prevalence in the healthy groups and blood donors group (2.4% versus 0.8% from hajah, and 0.6% from Aden). taiz, hadramout, and hodieda are large governorates, however, data for the prevalence were rare and inadequate |