الفهرس 
The prognostic value of ¹?F-FDG PET/CT volumetric measurements in NSCLC
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Abstract
Objective: To evaluate the prognostic significance of volume-based parameters of 18F-FDG PET/CT in early-stage non-small cell lung cancer (NSCLC). Background: The recurrence rate for early stage non-small cell lung cancer is high, with approximately 40% of stage I patients and 60% of stage II patients relapse within 5-years after curative resection. The aim of the present study was to evaluate if baseline PET-derived parameters can be used in the identification of high-risk patients and if they may be applied in clinical practice as a prognostic biomarkers in order to develop risk-adapted treatments. Methods: 18F-FDG PET/CT baseline scans of 150 surgically-treated early-stage NSCLC patients were evaluated as regards SUVmax, SUVmean, MTV and TLG of the primary tumor as well as of the whole body tumor burden (=primary tumor+all metastatic lymph nodes). The measurements were repeated three times using different thresholding methods. Disease-free survival (DFS) was assessed by the Kaplan-Meier method. The optimal cut-off value for the different PET parameters for prediction of recurrence was calculated using the receiver operating characteristic (ROC) curve analysis. 1-year and 3-years DFS rates were calculated Results: All PET-derived parameters were significantly associated with increased risk of recurrence. TLG showed the greatest accuracy in survival prediction (68%), followed by MTV (67%). Volume-based parameters of PET showed significantly better predictive performance than SUVmax. The 3-years DFS rates in patients with low and high SUVmax, SUVmean, MTV and TLG were 67% and 51%, 78% and 55%, 77% and 42%, 77% and 46% respectively