الفهرس 
”Philadelphia chromosome - positive B- Acute lymphoblastic leukemia in Egyptian patients”
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Abstract
Background: Little evidence exists regarding the prevalence, clinical outcomes and molecular response of adult patients with philadelphia chromosome (Ph) positive versus Ph negative B-Acute lymphoblastic leukemia (B-ALL) in our country. The aim of our study: Was to explore the prevalence of Ph by detection of minor bcr-abl gene (mbcr-abl) on it by qRT-PCR in Egyptian B-ALL cases, compare the Ph positive B-ALL patients with negative ones regarding baseline characteristics before treatment, detect the hematological and molecular responses in positive patients after receiving tyrosine kinase inhibitor (TKI) accompanied with classic chemotherapy, and compare treatment outcome and survival in both groups of patients. Patients and methods: Adult B-ALL patients presented to clinical oncology department at Cairo university were enrolled in the study during the period from January 2013 till January 2016. All patients underwent clinical assessment and baseline investigations including immunophenotyping by flow cytometry in addition to quantitative assessment of mbcr-abl gene expression using quantitative real-time polymerase chain reaction (qRT-PCR). Treatment and survival data were also collected. All patients received classic B-ALL treatment in addition to TKI (Imatinib) in Ph positive cases