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Abstract
Objective: The aim of this study is to investigate the correlation between cognitive abilities, health-related quality of life (HRQOL), gross motor skills; standing and walking, running, jumping domains and to compare between both age groups and sexes on previous variables in children with Down syndrome (DS). Subjects and Methods: Seventy children with DS of both sexes (37 boys and 33girls) were selected to be ranged in age from 8 up to 12 years, their IQ score was up to 70, able to understand and follow orders given during assessment, able to walk independently and to be free from visual, hearing or perceptual problems. They were divided into two age groups, group A (8 <10 years), and group B (10 < 12 years). The Rehacom was used to evaluate the cognitive abilities, the Pediatric quality of life inventory parent-proxy report (PedsQL TM) was used to evaluate HRQOL and the Gross Motor Function Measure-88(GMFM-88) was used to evaluate the gross motor skills. Results: There was a weak to moderate correlation between the cognitive abilities, HRQOL and GMFM in both age groups. The level of difficulty of attention / concentration was moderate, positively, significantly correlated with GMFM; standing and walking, running, jumping domains in both age groups. There was a moderate, positive, significant correlation between the physical score of HRQOL and walking, running, jumping domain in age group B, between the psychosocial score of HRQOL and standing domain in age group A. The results also showed that there was no age and sex difference on cognitive abilities, HRQOL and GMFM except the maximum reaction time, there was a significant decrease in boys, there was a significant increase in value of difficulty level in age group B. Conclusions: The cognitive abilities and HRQOL should be considered in the evaluation of children with DS in addition to gross motor skills as there was a correlation between them