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العنوان
Biochemical studies on some natural materials to ameliorate the toxic effect of Aflatoxins /
الناشر
Sara Magdy Mohamed Khalil ,
المؤلف
Sara Magdy Mohamed Khalil
هيئة الاعداد
باحث / Sara Magdy Mohamed Khalil
مشرف / Abdelmoneim Mohammed Nagieb
مشرف / Mohamed Saad Abdullatif
مشرف / Khaled Mostafa Elmeleigy
تاريخ النشر
2017
عدد الصفحات
149 P. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
Biochemistry
تاريخ الإجازة
22/3/2018
مكان الإجازة
جامعة القاهرة - كلية الزراعة - Agricultural Biochemistry
الفهرس
Only 14 pages are availabe for public view

from 189

from 189

Abstract

Aflatoxin contamination of animal diet is still a major problem for breeders since it has adverse effects on animal health and productivity. This study was carried out to investigate the effect of using coumarin and/or chlorophyll in rat diet against aflatoxicosis. Fifty four rats were randomly assigned into 7 groups ’’6 rats each’’ and group 5 ’’12 rats’’. group 1 was negative control. group 2 received water with coumarin 0.5%. group 3 received water with chlorophyll 0.5%. group 4 received water with coumarin 0.5% and chlorophyll 0.5%. group 5-8 received basal diet with aflatoxin B1 1000 ppb. group 6-8 were administered similar treatments as groups 2-4. The experiment ended after 8 weeks. Water and feed consumption were measured and feed conversion and efficiency rates were calculated. Random glucose level, total lipid, total cholesterol, triglyceride, total protein, creatinine and urea as well as ALT and AST activities were determined in serum. Histopathological examination of liver, kidney and pancreas was performed. The conversion and efficiency rates were significantly low in group 5 compared to groups 6-8. The serum glucose and cholesterol content as well as AST and ALT activities were elevated in group 5 compared to groups 6-8. The liver lesions observed in group 5 represented in vacuolation and necrosis were alleviated in groups 6-8. The necrosis and inflammatory cells infiltration in pancreas of group 5 were absent in groups 6-8. In conclusion, the coumarin and or chlorophyll possessed a hepatoprotective effect against aflatoxincosis