الفهرس 
Expression of Podoplanin in laryngeal squamous cell carcinoma and premalignant lesions; Histological and Immunohistochemical Study
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Abstract
Background:The expression of podoplanin in human cancers and its relationship with tumor invasion raises the possibility that podoplanin expression could be used as a biomarker for diagnosis and prognosis. Aim: To investigate the immunohistochemical expression of podoplanin in laryngeal squamous cell carcinoma (SCC) and premalignant lesions and to correlate the expression of podoplanin in laryngeal SCC with clinicopathological factors. Materials and method:This study included a total of 60 archived, formalin fixed, paraffin embedded tissue blocks (40 cases of laryngeal SCC and 20 cases of premalignant lesions). The samples were immunohistochemically analyzed forpodoplanin expression. Results:Podoplanin expression was significantly higher in laryngeal SCC (90%) than laryngeal dysplastic lesions (55%) (P value=0.002). The expression of podoplaninwas significantly increased with the higher grade of dysplasia(P value=0.016). A significant positive correlation was detected between podoplanin expression in laryngeal SCC and depth of tumor invasion (P value=0.035), and tumor stage (P value=0.026). Conclusions:Podoplanin is a potential prognostic marker in laryngeal SCC. In addition, evaluation of podoplanin along with histopathological evaluation can provide additional information like malignant transformation which cannot be detected merely by clinical and histopathological analysis