الفهرس 
Estimation of antibacterial activity of some Egyptian plant extracts against selected antibiotic-resistant bacteria
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Abstract
Successive leaf extracts of three Egyptian plant species: Datura stramonium L., Withania somnifera (L.) Dun. in DC. and Ziziphus spina-christi (L.) Willd.were studied for their antimicrobial activity against susceptible and Multi-Drug Resistant (MDR) bacteria isolated from chickens. Four bacterial spp. namely: Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and Salmonella sp. were isolated from 463 different chicken samples. The sensitivity of these bacterial isolates was tested against 11 types of antibiotics: Ampicillin, Amoxicillin, Cefaclor, Gentamicin, Amikacin, Tobramycin, Ciprofloxacin, Nalidixic acid, Erythromycin, Tetracycline and Vancomycin.The isolates of E. coli, S. aureus, P. aureugenosa and Salmonella sp. showed notable bacterial resistance against the used antibiotics with percentages: (68.18%), (59.09%), (54.54%) and (54.54%) respectively. Chloroform extractof Datura stramonium showed the highest antibacterial activity against all the studied bacterial isolates with MICs values varying from 75.0 to 0.037 mg/ml. The chloroform extracts of the Datura stramonium which showed highest antibacterial effect applied to GC-Mass foridentification of fatty acids and hydrocarbons. 37 fatty acid among the major compounds detected are: Phytol (16.64 %), Palmitic acid (16.21% ) and linolenic acid (13.57%). Thirty three Hydrocarbon and Sterols, Twenty nine Hydrocarbons and Four Sterols were detected. Namely: Phytol isomers (16.89%), 1- hexanol (9.85%) and Decane (8.23%) were the major hydrocarbons in the studiedDatura stramonium. In conclusion, the present work indicated the potentiality of Datura stramonium chloroformextract as a promising national source for drug industry to produce antibiotics to be used against pathogenic multidrug resistant bacteria