الفهرس 
Role of pre-operative oral pregabalin in reducing inhalational anesthetic requirements in elective abdominal hysterectomy under general anesthesia :
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Abstract
Background: Pregabalin and gabapentin are anti-convulsants with membrane stabilizing and anti-nociceptive effects. Pregabalin has analgesic, anxiolytic and sleep modulating activities. Previous studies showed that perioperative pregabalin reduced the opioid consumption with better postoperative analgesia. Inhaled Isoflurane has many side effects. Thus, reducing inhaled Isoflurane requirements will achieve many advantages by decreasing its side effects and facilitating rapid recovery after general anesthesia with shorter emergence time. Objectives: To compare the efficacy of preoperative oral pregabalin versus placebo in reducing intraoperative Isoflurane requirements needed to maintain intraoperative hemodynamic stability (Blood pressure and heart rate within ± 20% of baseline measurements) in female patients ASA I/II undergoing elective abdominal hysterectomy surgery under general anesthesia. Methods: The patients attended at the pre-anesthesia room 2 hours before the procedure. Standard monitoring was applied to the patient. A 20 Gauge cannula was inserted peripherally and the patient was pre-medicated with intravenous ranitidine and metoclopramide. The anesthesiologist administering drug and conducting anesthesia was blinded to the drug administered. Patients were equally divided into two groups and pre-medicated by pregabalin. After anesthesia, intraoperative IPPV (using MAQUET Flow-I anesthetic machine) to maintain PaCO2 within normal range and BIS values within the range of 40-60, and using end-expired Isoflurane concentration as a guide to measure the intraoperative inhalational anesthetic requirements to maintain hemodynamic stability (Bp and HR±20% of the baseline) and postoperative analgesic requirement and side effects