الفهرس 
Correlation between salivary and blood glucose levels in adults with diabetes mellitus and prediabetics
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Abstract
Background: Diabetes is most rapidly growing chronic disease of the century. Diabetics are at an increased risk of developing numerous complications, resulting in increased health care expenditures, economic burden, and higher mortality. Aim: the aim of this study is to determine the diagnostic accuracy of salivary glucose estimation for diagnosis and/or follow up of diabetes & prediabetes. Subject and methods: A comparative study including 204 adults in 3 groups (104 patients with type 2 diabetes, 50 prediabetics, 50 non-diabetic controls) aging 18-65 years. The participants were interviewed about their socio-demographic, comorbidities, & drug treatment using a predesigned questionnaire. Salivary & blood samples were collected and analyzed. Results: Mean salivary glucose was observed to be 23.40 ± 12.755 mg/dl in control group, 42.68 ± 20.830 mg/dl in prediabetic group and 59.32 ± 19.147 mg/dl in diabetic group with significant difference between the 3 groups (P value < 0.001). Salivary glucose level was significantly correlated to FBS with strong positive association (r= 0.67 & P value <0.001 in control group, r= 0.56 & P value <0.001in diabetic group and r= 0.36 & P value {u2248}0.01 in pre-diabetic group). Salivary glucose could differentiate non-diabetics from diabetics (AUC: 0.928, P value < 0.001) with sensitivity (94.2%) and specificity (62%) & differentiate non-diabetics from prediabetics (AUC: 0.928, P value < 0.001) with sensitivity (94.2%) and specificity (62%). Conclusions: Evaluation of salivary glucose can be an effective and non-invasive alternative for screening, diagnosing and monitoring of diabetes & prediabetes