الفهرس يوجد فقط 14 صفحة متاحة للعرض العام
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المستخلص
Metformin hydrochloride (MF) is a potent antidiabetic drug with pleiotropic effect imparting it powerful anticancer activity. Recent studies attempt to disentangle the polypharamacological mechanisms responsible for MF anticancer activity, nominating it as a potential candidate for drug repurposing. To our interest, novel data showed that employing MF as an adjuvant therapy concurrently with conventional chemotherapy prove effective treatment regimen for recurring colorectal cancer (CRC). According to biopharmaceutical classification system (BCS), MF belongs to class III i.e. high solubility and low permeability. Thus, it might be conceivable to develop a system improving the pharmacokinetic properties of the drug hence fortifying its pharmacodynamic effect. Nanoparticles (NPs) have been proven to be an efficient delivery system with few side effects for several anticancer drugs. In this study, MF-loaded NPs have been prepared via ionic gelation method using chitosan (CS) and Pluronic® (F-108 or P-123) as a carrier. Effects of different formulation parameters such as concentration of Pluronic® and drug on the properties of the prepared NPs were evaluated. In fulfillment of system optimization, the developed NPs were analyzed using a full factorial design. Results help in understanding the independent variables that affect significantly the tested outputs namely, entrapment efficiency (EE%), particle size (PS) and zeta-potential (ZP)