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Abstract High fat diet may affect the weaning of mechanical ventilation in critically-ill ventilated children with respiratory failure due to pulmonary disease. We aimed to compare the effect of a high fat, low carbohydrate enteral feeding fortified with micronutrients to standard enteral feeding with normal macronutrient distribution on carbon dioxide tension and duration of ventilation.Fifty oneventilated children (aged 1 month to 12 years) with respiratory failure secondary to pulmonary disease who could be enterally fed ;in Cairo University Pediatric intensive care unit; were enrolled in this study. They were divided into two groups:group A: included twenty five patients who received isocaloric high fat low carbohydrates feeding (30% carbohydrates, 50% fats, 20% proteins) with zinc and omega-3 fatty acids supplementation.group B: included twenty six patients who received standard isocaloric feeding protocol (60% carbohydrates, 20% fats, 20% proteins) with no specific micronutrient supplementation.Results showed thatgroup A had a significant reduction ofcarbon dioxide tension by 19.2% andsignificantly shorter duration of mechanical ventilationby 35.5%. Mild postprandial hypertriglyceridemia was detected among the high fat feeding group with some gastrointestinal intolerances not affecting the adequacy of nutritional support delivery to this group |