الفهرس 
Pediatric sepsisOnly 14 pages are availabe for public view
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Abstract
Sepsis is a life-threatening organ dysfunction caused by a deleterious host response to infection. It is a leading cause of morbidity and mortality in critically ill pediatric patients. Fast and precise recognition of sepsis by biomarkers may save lives, especially if it can be a point-of-care test.
Despite all effort, there is to date no solitary biomarker nor combination of biomarkers available for correctly discriminating sepsis from trauma, tissue damage. Levels of the readily available sepsis biomarkers either rise too slowly or DROP too fast for clinicians to be certain about catching a sepsis in development or for clinicians to be able to eliminate sepsis as a reason for deterioration.
In this study we aim to assess reliability of SAA and pro-ADM as a diagnostic and prognostic biomarker of sepsis in pediatric intensive care unit of Menoufia University hospital in the period from June 2020 to May 2021.
This study was conducted on 96 patients divided into 2 subgroups: -
I) Patient group: included 65 patients admitted to PICU (33 male,32 female) which is further subdivided into 3 groups:
Sepsis: includes 23 patients; 11 were males and 12 females.
Sever sepsis: includes 18 patients; 10 were males and 8 females.
Septic shock: includes 24 patients; 12 were males and 12 females.
II) Control group: including 31 healthy children (15 males, 16 females) of matched age and sex with patient group.
Inclusion criteria:
Children aged from 1 month to 16 years.
Patients with established diagnosis of sepsis or severe sepsis or septic shock at the time of admission to the pediatric ICU based on the American college of critical care medicine and international pediatric SCC definitions for sepsis (Goldstein et al., 2005)
Exclusion criteria:
Patients who have no blood samples for measurement of markers within 24 hours of admission to PICU.
Patients not fulfill diagnostic criteria for sepsis