الفهرس 
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Abstract
Auminum phosphide (ALP) is a solid pesticide that is used to kill bugs. In Egypt, ALP is used a lot to keep bugs and rodents away from grains. It comes in ”grain tablet” form, which is a kind of tablet. In developing countries, more and more people are taking ALP tablets to kill themselves. This is because it is used a lot, is free to get on the market, and is cheap.
Aluminum phosphide reacts with acids or water to make phosphine gas, which is very dangerous. It stops cytochrome oxidase and cytochrome C from working in the mitochondria, which stops cells from breathing. Also, oxidative stress is thought to be one way that phosphides are harmful (Sciuto et al., 2016).
Aluminum phosphide poisoning is very deadly. The reported death rate ranges from 37% to 100%. More than 90% of people die in the first 24 hours, mostly because of a problem with the heart’s rhythm. Even though research has been going on for a long time, no effective treatment for this poison has been found yet.
The goal of the study was to compare the effects of giving IV amiodarone and IV MgSO4 infusions to prevent heart rhythm problems in people with acute ALP toxicity.
This study looked at 75 adults who were hemodynamically unstable and had ALP toxicity. Patients were split into three groups, A, B, and C, with each group having 25 people.
• group A was used as a control group. They didn’t get any MgSO4 or amiodarone as a preventative measure, but they did get all of the important treatments used for regular acute AlP toxicity, like anti-arrhythmic drugs when they were needed.
• group B got six grammes of MgSO4 through an IV over the first 24 hours after being admitted.
• group C received 150 mg IV as loading bolus of amiodarone then IV infusion with the dose 1mg /min first 6hours then with dose 0.5 mg/min for the following 18hours.
Summary of our results:
Age, sex, dosage, and the amount of time between ingesting AlP and being admitted to the ICU were not substantially different across the three groups. There was a negligible difference in the incidence of dyspnea, chest discomfort, vomiting, and abdominal pain across the three groups.
The three groups’ differences in GCS, HR, MAP, temperature, and O2 saturation were negligibly different.
The differences between the three groups in Hb, WBCs, platelets, prothrombin time and INR, random blood glucose, creatinine, AST, ALT, TSH, pH, PCO2, and HCO3, urea, and electrolytes (Ca, Na, K, P, Mg, and Cl) were negligible.
Vasopressor, EF, and showed little differences across the three groups.
The three groups’ differences in hospital stay and mortality rate were not statistically significant. Each patient in each of the three groups required MV.
There were no appreciable differences between the three groups in terms of sinus bradycardia, first- and second-degree atrioventricular block, atrial premature contraction, sinus tachycardia, atrial fibrillation, junctional rhythm, idioventricular rhythm, ventricular premature contraction, ventricular fibrillation, asystole following AF, left bundle branch block, and right bundle branch block