الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Obesity is a complex health issue to address, it is a serious and chronic disease that can have a negative effect on many systems in your body. Overweight and obesity may increase the risk of many health problems, including diabetes, heart disease, osteoarthritis and certain cancers. Obesity is increasing at an alarming rate throughout the world. Today it is estimated that there are more than 300 millionobese people world-wide. Obesity is regarded as a disorder of lipid metabolismand the enzymes involved in this process could be targeted selectively for thedevelopment of anti-obesity drugs. However, most of the anti-obesity drugs thatwere approved and marketed have now been withdrawn due to serious adverse
effects. The naturopathic treatment for obesity has been explored extensively since ancient times and gaining momentum in the present scenario. Traditonal medicinal plants and their active phytoconstituents have been used for the treatment of obesity and their associated secondary complications. Some active medicinal plants and their respective bioactive compounds were also tested by clinical trials and are effective in treatment of obesity. This review focus on natural phyto-extracts with their mechanism of action and their preclinical experimental model for further scientific research. Obesity is a complex disease caused by the interaction of a myriad of genetic, dietary, lifestyle, and environmental factors, which favors a chronic positive energy balance, and leads to increased body fat mass. The incidence of obesity is rising at an alarming rate and is becoming a major public health concern with incalculable social costs. Indeed, obesity facilitates the development of metabolic disorders such as diabetes, hypertension, and cardiovascular diseases in addition to chronic diseases such as stroke, osteoarthritis, sleep apnea, some cancers, and inflammationbasedpathologies. Recent researches demonstrated the potential of natural products to counteract obesity. Multiple-natural product combinations may result in a synergistic activity that increases their bioavailability and action on multiple molecular targets, offering advantages over chemical treatments. In this review, we discuss the anti-obesity potential of natural products and analyze their mechanisms. Obesity is a complex disease of great public health significance worldwide: It entails several complications including diabetes mellitus type 2, cardiovascular dysfunction and hypertension, and its prevalence is increasing around the world. The pathogenesis of obesity is closely related to reactive oxygen species. The role of reactive oxygen species as regulatory factors in mitochondrial activity in obese subjects, molecules taking part in inflammation processes linked to excessive sizeand number of adipocytes, and as agents governing the energy balance in hypothalamus neurons has been examined. Plant products may be a good natural alternative for weight management and a source of numerous biologically-active chemicals, including antioxidant polyphenols that can counteract the oxidative stress associated with obesity. This review presents polyphenols as natural complementary therapy, and a good nutritional strategy, for treating obesity without serious side effects.