الفهرس 
Children with severe gastroenteritis and dehydrationOnly 14 pages are availabe for public view
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Abstract
Acute gastroenteritis (AGE) is a major cause of morbidity and mortality, with 3–5 billion cases and nearly 2 million deaths occurring each year in children under 5 years of age, mostly in the developing world. The most important and dangerous complications related to AGE are dehydration, metabolic acidosis, and electrolyte disturbances.
One of the most common causes of pediatric acute kidney injury (AKI) is kidney hypoperfusion (prerenal AKI). By this mechanism, AGE could underlie about 12% of AKI in children. Hospitalized children who develop AKI could experience longer hospital stays and higher mortality in the short term and an increased risk of chronic kidney disease (CKD), hypertension, and proteinuria in the long-term period.
Human ”Neutrophil gelatinase-associated lipocalin” (NGAL, lipocalin 2) was originally identified as a 25-kDa protein covalently bound to gelatinase from neutrophils. It is mainly expressed by neutrophils and various epithelial cells, and variable degrees of NGAL gene expression are demonstrated in human tissues like the uterus, prostate, salivary glands, lung, trachea, stomach, colon, and kidney. It was shown that NGAL was a potent early biomarker of renal injury in numerous clinical studies.
This study aimed to investigate the urine NGAL concentrations as an early biomarker of prerenal acute kidney injury in severely dehydrated pediatric patients with acute gastroenteritis in critically ill children. A cross-sectional study was conducted on 69 children, whose ages ranged from 1 to 108 months at the pediatric intensive care unit (PICU), Faculty of Medicine, Menoufia University after obtaining consent from their parents and caregivers during the period study from august 2020 till March 2021.
The studied patients were classified into group I: which included 24 children with Gastroenteritis with Non-Acute kidney injury. group II: included 45 children with Gastroenteritis with Acute kidney injury (AKI).