الفهرس 
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Abstract
Prothrombotic extracellular matrix proteins exposed to vascular injury, which facilitate platelets adhesion and activation. In addition to minimizing blood loss, a major function of platelets is to promote healing of the damaged tissue. Which release cytokines, chemokines and growth factors from platelet granules (Machlus et al. 2013).There are 3 major types of secretory granules in platelets including the following: (i) α-granules, containing many growth factors and cytokines; (ii) dense c-granules, which release calcium, serotonin polyphosphates, pyrophosphates, adenosine diphosphate (ADP) and adenosine triphosphate; and (iii) lysosomes, which contain a number of hydrolytic enzymes (Mumford et al. 2015). There are 50-80 α-granules per platelet with a typical diameter of 200-500 nm that can be released intracellularl or extracellular (Yeaman et al. 2014).