الفهرس 
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Abstract
Background: Cardiovascular diseases are the leading cause of death worldwide. Acute coronary syndrome is one of common manifestation of these diseases, which includes ST-elevation myocardial infarction (STEMI), non-ST elevation myocardial infarction, and unstable angina. Despite the advances in treatment strategy, STEMI has the highest mortality rate among acute coronary syndrome. Early reperfusion therapy and reestablishment of blood flow in the closed vessels are the crucial treatment for patients with STEMI. Percutaneous Coronary Intervention (PCI) and Thrombolysis (TL) are two treatment methods used for STEMI. Objective: the aim of this study was to assess prognosis of STEMI after two years of the event of MI. compared long-term outcomes between primary PCI and thrombolytic therapy in items of major adverse cardiovascular events which include AMI, stroke, cardiovascular death, rehospitalization with unstable angina or reperfusion and heart failure. Patients and methods: Methods: This was a retrospective, single center study carried out between December 2020 and December 2021 and conducted on 91 patients. 46 patients received thrombolytic therapy and 45 patients underwent coronary reperfusion by primary PCI and rescue PCI. All patients diagnosed with STEMI 2 years ago, admitted to CCU of Cardiovascular department at Mansoura Specialized Medical Hospital, who received reperfusion therapy either primary PCI or thrombolytic agent within 12 hours of symptoms onset and alive at discharge. Results: The present study revealed that there was significance increase in frequency of MACE among thrombolytic group compared to PCI group, there was significant elevation of EF on follow up in PCI group compared to thrombolytic group and PCI effectively reduced dyspnoea. Anterior STEMI was associated with significant reduction of EF on follow up and more cardiac rehospitalization compared to inferior STEMI group. Conclusion: STEMI remains an important cause of mortality and morbidity. Reperfusion type affect the long-term outcomes of the patients, as the PCI is significantly decreased the MACE and increased the EF. Site of infarction also affects the outcome, as the anterior STEMI had more reduction in EF and worse outcomes with more rehospitalization.