الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
Heterocyclic compounds containing nitrogen and/or sulfur including pyrimidines represent a major component of many natural products and biologically active molecules [1].These compounds have been widely used as agrochemicals,flavors and stains but they were mainly applied as drugs in medicinal chemistry [2]. The pyrimidine nucleus is a 1,3-diazine containing two nitrogens at 1 and 3 positions. As a response to the great importance of pyrimidines in many aspects, a large number of synthetic procedures have been designed for the efficient synthesis of pure pyrimidine derivatives. The barbituric acid and thiobarbituric acid derivatives exhibited a wide range of biological activities and consequently they are considered one the most important examined drugs [3 Cancer is one of the most serious diseases that eventually lead to death.It involves uncontrolled cell growth forming injurious tumers that may spread in body organs. Pyrimidine derivatives have been greatly involved in the cancer therapy and showed excellent antoxidant and antimicrobial activity [4].Breast cancer is.