الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
Hepatitis C is a global health problem as reported by the World Health Organization WHO), three to four million people are newly infected with the hepatitis C virus (HCV each year and 130-170 million people are chronically infected. Each year more than 350,000 people die from liver diseases related to hepatitis C (Campione et al., 2019).Hepatitis C Virus (HCV) is a small RNA virus, which is enveloped. It is a member of the family Flaviviridae. Its genome is a positive single-strand RNA that encodes a polyprotein of approximately 3000 amino acids. This polyprotein is broken down into structural (E1, E2, and Core) and non-structural (p7, NS2, NS3, NS4A, NS4B, NS5A NS5B) proteins by cellular and viral proteases. A characteristic feature is an ability to make newly mutated endogenous strains emerge. Owing to this genomic heterogeneity and antigenic variation, it is challenging to generate a successful HCV vaccine (Moradpour et al., 2007; Nayak, 2015).