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العنوان
Clinical utility of interferon gamma assay for early detection of tuberculosis in immunocompromised cancer patients /
الناشر
Noha Saeed Ali Mohamed ,
المؤلف
Noha Saeed Ali Mohamed
هيئة الاعداد
باحث / Noha Saeed Ali Mohamed
مشرف / Magdy Mohammed Saber
مشرف / Hadir Al Mahalawy
مشرف / Hala Aziz Shokralla
تاريخ النشر
2019
عدد الصفحات
97 P. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
علم الأورام
تاريخ الإجازة
11/12/2019
مكان الإجازة
جامعة القاهرة - معهد الأورام القومى - medical oncology and malignant hematology
الفهرس
Only 14 pages are availabe for public view

from 135

from 135

Abstract

Introduction Tuberculosis (TB) is an infectious disease that usually affects the lungs, the relationship between TB and cancer is of dual nature. Patients with malignant diseases have an increased risk for diseases caused by TB. Patients with depressed cellular immunity such as those who have lymphoproliferative disorders, transplant patients and patients on immunosuppressive therapy are at particular risk. For latent tuberculosis infection (LTBI) diagnosis, interferon gamma release assay (IGRAs) may be used as part of the overall risk assessment to identify individuals for preventive treatment (Hong et al, 2016). Patients and methods Quantiferon test was done for two immunosuppression group: solid malignancy (30 patients) and hematological malignancy (30 patient), followed with PCR sputum for positive patient to differentiate active from latent tuberculosis. Results Twenty patients were positive (11 solid cancers and 9 hematological malignancy) with p value 0.540, only two patients from them positive PCR