الفهرس 
Title : Study of the possible protective effect of formoterol in streptozotocin-induced sporadic Alzheimer{u2019}s
ContentsOnly 14 pages are availabe for public view
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Abstract
Alzheimer’s disease (AD) is characterized by progressive cognitive decline and pathological deposition of amyloid plaques as well as neurofibrillary tangles. Most of AD cases are sporadic, resulting from overlap of various environmental and genetic factors. Intra-cerebroventricular(ICV) injection of streptozotocin (STZ) leads to insulin resistance brain state accompanied by memory decline, oxidative stress, and neuro-degeneration which mimic the pathologies associated with sporadic Alzheimer’s disease (SAD).In the current study, the protective effects associated with formoterol administration (25,50,100 æg/kg/day, i.p) for 21 days, in ICV-STZ(3mg/kg, ICV) injected mice, were studied. Formoterol-induced improvement in cognition was confirmed using Morris water maze and Y maze together with histopathological evidences. Moreover, prominent declines in oxidative stress, neuro-inflammation, and apoptotic parameters were recorded upon its injection in STZ-induced SAD mouse model