الفهرس 
Title : Bisphenol - a levels in food and feed and its hormonal disruption in male and female rats
CONTENTSOnly 14 pages are availabe for public view
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Abstract
Bisphenol A (BPA) is a pollutant which causes negative effects on human health. The aim of the present study is to determine BPA levels leaching of several kinds of canned foods, beverages, baby bottles and feed in local Markets by using gas chromatography-mass spectrum (GC/MS/MS). Also it was carried out to perceive the biological effects of administration of BPA on reproductive organs and hormonal levels in male and female albino Spargue-Dawely rats. The protective effect of rose water and clove oil on BPA was also investigated. In More than 130 different samples taken from Egyptian markets, the highest mean BPA level was found in chicken cocktail sausaged (710.59 ppb) which was given highly significant results with regard to all other food samples result, whilst the lowest was for tomato ketchup at (5.75 ppb). The leaching of BPA from baby bottles to milk was found to be highest (123.53 ppb) compared with other baby drinks. The thermal effect on number of uses on BPA migration indicated a positive relationship between them. The concentration of BPA in milk has reached 1046.79 ppb after baby bottles were used 100 times at 90 C̊. Ninety rats were divided in to 9 groups of males and 9 for females. Rats were exposed to different oral gavage route 3 times a week by doses of BPA (20 æg, 20 mg, 200 mg) /kg b.wt for 6 weeks BPA. BPA induced significant decrease in total and free testosterone (T) in male rats, in contrast of significant increase in thyroid stimulating hormone (TSH), Follicle stimulating hormone (FSH), progesterone, estrogen (E2) and prolactin (PRL) compared to control groups. Histopathological examination revealed that rose water or clove oil reduced testes and ovary damages induced by BPA. Rose water and clove oil components were scanned using GC/MS which showed that rose water and clove oil contain phenols , flavonoids and these inevitably confirms that a prominent role in preventing the damage during treatment