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Abstract Background: Although not well known, post-laminectomy syndrome (PLS) is an important cause of chronic back pain, which may lead to decreased quality of life, disability and psychological disorders. The purpose: This study aimed to determine and compare between the effectiveness of core stabilization and McKenzie’s exercises on intensity of pain and disability in patients with PLS. Methods: Forty five patients with PLS with age ranged from 30 to 40 years were enrolled in this study and equally divided into three groups: group (A) received conventional physical therapy program (Ultrasound, TENS, and moist heat), group (B) received lumbar stabilization exercises and group (C) received McKenzie exercises (three sessions per week for four weeks). Intensity of pain was assessed using Visual Analogue Scale (VAS), disability was assessed using the Oswestry disability Questionnaire. Transversus abdominis (TrA) activation capacity and lumbo-pelvic stability were assessed using pressure biofeedback unit. Results: There were a statistically significant improvement in the mean values of pain intensity and functional disability scores in the three groups (p<0.05) post treatment. On comparing among groups, group B showed significantly greater improvement of pain intensity and functional disability scores than group C and group A (p<0.05) post treatment. Also, there was a statistically significant improvement in the mean value of TrA activation capacity in the three groups post treatment while there was no statistically significant difference among groups post treatment. Moreover, there was a statistically significant improvement in the mean value of lumbopelvic stability in group B only when using double bent leg lift test and in both group B and group C during using double bent leg lower test post treatment but there was no statistically significant difference among groups during using both double bent leg lift and double bent leg lower tests |