الفهرس 
Title : Analytical study of some drugs containing carboxylic acid derivatives
ContantsOnly 14 pages are availabe for public view
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Abstract
This thesis comprises three parts 1) Introduction and literature review,2) The experimental work of thiocolchicoside, 3) the experimental work of atracurium besylate, followed by the references and an Arabic summary. Part I: Introduction and literature review. This part includes a general introduction about the chemistry, mode of action and literature review of some drugs containing carboxylic acid derivatives: 1) Thiocolchicoside and 2) atracurium besylate. Part II: Thiocolchicoside. In this part, spectrophotometric and chromatographic methods were developed for the quantitative determination of thiocolchicoside in pure form, in presence of its degradation products and in its pharmaceutical dosage form. Section (1): Preparation of degradation product of thiocolchicoside. In this section, the conditions required for the degradation of thiocolchicoside were studied, then the degradation product was isolated and its structure was confirmed using TLC, IR and MS. Section (2): Determination of thiocolchicoside in presence of its degradation product by first derivative spectrophotometry. This method utilized first derivative spectrophotometry (D1) where the peak amplitude at 412.8 nm was used for the determination of thiocolchicoside. Section (3):Determination of thiocolchicoside in presence of its degradation product by dual wavelength spectrophotometry. In the absorption spectrum of thiocolchicoside, there is a significant difference in absorption in two wavelengths (256.8 nm and 290.8 nm), while the absorption of its degradation product at these selected wavelengths is the same