الفهرس 
Title : Bone Regenerative Capacity of Gingiva-Derived versus Bone Marrow-Derived Mesenchymal Stem Cells in Critical Sized Tibial Bone Defects of Rabbits (An animal study)
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Abstract
The present study was conducted to compare the bone regenerative capacity of gingiva as well as bone marrow-derived mesenchymal stem cells loaded on NanoBone scaffold as compared to the unloaded NanoBone scaffold in critical-sized tibial bone defects of a rabbit model. To achieve this aim, forty one healthy adult male New Zeeland white rabbits, of an average weight 2.5-3 kgs and having an average age of six months, were used. Five rabbits were used for stem cell isolation, while in the remaining thirty six rabbits, circular unicortical critical sized bone defects (6 mm in diameter) were unilaterally created in their tibia. The animals were then divided randomly into three groups (12 rabbits each), according to the treatment modality, as follows: group I: Unloaded NanoBone Scaffold, group II: GMSCs Loaded on NanoBone Scaffold, and group III: BMSCs Loaded on NanoBone Scaffold. Four rabbits from each group were then terminated at three postoperative time points (2, 4 & 6 weeks). Specimens were then processed and evaluated through histological (Hematoxylin & Eosin and Masson{u2019}s trichrome stains) examination, histomorphometrical analysis, histochemical (Alcian blue/PAS stain) examination as well as assessing CD31 gene expression using qRT-PCR