الفهرس 
Title : Pancreaticobiliary reflux in disease gallbladder compared to normal gallbladder
AbstractOnly 14 pages are availabe for public view
 |  | from | 209 |  |  |
| | | from | 209 | | |
Abstract
Background: Pancreatico-biliary reflux (PBR) leads to biliary tract and gallbladder mucosa chronic injury that could play a role in the etiology of gallstones, chronic gallbladder disease and ultimately gallbladder cancer, constituting only different continuous stages of a common pathologic entity. Objective: To compare the levels of amylase and lipase in gallbladder{u2019}s bile in diseased gallbladders and healthy gallbladders, derived from donors of living donor liver transplant, to establish a comparison study to assess how far does the pancreatico-biliary reflux affect the biliary system and what is the accepted harmless range, if present, of that reflux. PATIENTS AND Methods: 34 patients with chronic calcular cholecystitis and another 34 with healthy gallbladders were submitted to cholecystectomy. Amylase and lipase levels were measured in serum and bile, aspirated from the gallbladder, the normal range of serum amylase is 70-340 U/L while for serum lipase is 0-160 U/L. Histopathological examination of all gallbladders was done with routine hematoxylin and eosin stains. Simple comparisons between groups were performed with t-test. A correlation study between serum and bile amylase and lipase was done in both groups separately. Results: Both amylase and lipase levels collected from serum and bile of diseased gallbladders were markedly elevated in comparison with those of normal gallbladders, ten folds for amylase and three folds for lipase (p<0.001). Conclusion: Pancreaticobiliary reflux exists in normal population within a limit, exceeding that limit will turn the condition into a pathologic phenomenon leading to biliary diseases