الفهرس 
The possible protective effect of vanillin and chlorophyllin against the genotoxicity, cytotoxicity and oxidative stress induced by methotrexate in albino mice
AbstractOnly 14 pages are availabe for public view
 |  | from | 100 |  |  |
| | | from | 100 | | |
Abstract
Background: Although chemotherapeutic drugs are effective in cancer treatment, toxic side effects remain as a main problem for patients treated with these drugs. Methotrexate (MTX) is a well known and widely used anticancer drug. Despite its effectiveness in cancer treatment, it has serious side effects particularly hepatotoxicity, nephrotoxicity and genotoxicity. The proposed mechanism of MTX cytotoxicity is due to oxidative stress. Antioxidants are substances that have the ability to scavenge free radicals leading to reduction in oxidative stress. Aim of the study: The present study aimed to investigate the ability the antioxidants vanillin (VAN), chlorophyllin (CHL) and their combination to ameliorate the adverse toxic effects induced by MTX in the liver, kidney, and bone marrow of mice. Methods: Male mice were treated orally with VAN (392.5 mg/kg), CHL (700 mg/kg) or their combination for three consecutive days before single intraperitoneal dose of MTX (10 mg/kg), and sacrificed 24 hours later. Serum AST, ALT, urea, creatinine were estimated. Kidney injury molecule-1 (KIM-1) was assessed in kidney tissue