الفهرس 
Comparative histological study on the effect of erythropoietin versus curcumin
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Abstract
Background and Aim of work: Peripheral nerve injuries are commonly encountered in clinical practice due to several causes such as accidental trauma or surgery. They are often associated with poor nerve regeneration and inadequate functional recovery. Therefore, this study was planned to evaluate and compare the possible protective effect of erythropoietin (EPO) versus curcumin on crush injury of the sciatic nerve in a rat model. Material and Methods: Thirty six adult male albino rats were randomly allocated into 5 groups: group I (control, sham-operated), group II (sciatic nerve injury (SNI), group III (untreated), group IV (SNI+ EPO) and group V (SNI + curcumin). Sciatic Nerve Injury (SNI) was induced by clamping the right sciatic nerve with a sterile tissue forceps for 1 minute. After 24hrs, group IV was injected i.p with EPO (5000IU/kg) daily for two weeks. group V was given curcumin (40mg/kg) orally for two months. The compound muscle action potential (CMAP) amplitudes were recorded at the end of each experimental period. Sciatic nerve specimens were then processed for hematoxylin and eosin, osmic acid stain, toluidine blue stain and immunohistochemical staining for neurofilament (NF) antibody, number and diameter of nerve fibers, ratio of the myelin area to the nerve fiber area as well as area percent and optical density of NF were measured and statically analyzed