الفهرس 
Formulation and evaluation of ocular drug delivery systems of certain antibiotics
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Abstract
Levofloxacin is a third generation fluoroquinolone antibiotic with bactericidal activities on a wide range of bacterial pathogens; therefore, it can be used to prevent and treat potentially sight-threatening bacterial infections. The drug is available as 0.5% aqueous eye drops but its bioavailability from this dosage form is minimized by the action eye blinking and nasolacrimal drainage. Thus, frequent instillation is necessary to preserve adequate level of the drug at the site of action which leads to patient incompliance. Therefore, the aim of the current study was to develop controlled release ocular delivery systems of levofloxacin suitable for once daily administration and resistant the washout mechanisms of the eye. Such systems will provide a convenient dosing regimen attractive to patients requiring long-term as well as short-term therapy