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Abstract Cervical spondylotic myelopathy (CSM) is the most common cause of spinal cord dysfunction. It is also the leading cause of spinal-cord-related disability in the elderly. It results from the degenerative narrowing of the spinal canal, causing spinal cord compression in a slow, progressive manner. The degree and location of spinal cord compression is heterogeneous. Spinal cord compression can result from ventral pathologies such as herniated disks and disk osteophyte complexes or from dorsal compression from facet and ligamentum flavum hypertrophy. These changes can be confined to 1 level or can involve multiple levels. Cervical spondylotic myelopathy is the most common cause of myelopathy in adults over 55 years, causing progressive disability and impairing the quality of life. Here we address some of most important aspects of this disease, calling attention to pathophysiology, the natural history, presentation, differential diagnosis, clinical assessment, and treatment |