الفهرس 
Title : Role of syndecan-1 in modulating the interaction between monocytes and breast cancer stem cells
AbstractOnly 14 pages are availabe for public view
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Abstract
Inflammatory breast cancer (IBC) is the most aggressive form of breast cancer and is characterized by a high infiltration of CD14+ monocytes. A growing body of evidence indicates that tumor-associated macrophages (TAMs) are classified into two major phenotypes, tumor inhibiting M1 and tumor promoting M2. The transmembrane heparan sulfate proteoglycan Syndecan-1 (Sdc-1) expression is induced in a variety of cell types during development and tumor progression and plays an essential role in regulation, recruitment and activation of monocytes in tumor microenvironment. We have recently shown that Sdc-1 is overexpressed in tumor tissue samples of IBC vs non-IBC. However, the role of Syndecan-1 in mediating macrophage polarization is still poorly studied. In the present study, we have employed siRNA approach to silence Syndecan-1 expression in the human breast cancer cell lines MDA-MB-231 (non-IBC) and SUM- 149 (IBC) cells