الفهرس 
Title : Immunomodulatory effects of mesenchymal stem cells in a model of acetic acid- induced colitis in rats /
ContentsOnly 14 pages are availabe for public view
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Abstract
Mesenchymal stem cells (MSCs) have lately emerged as a therapy for various pathological conditions.The present study examined the therapeutic effects of bone marrow mesenchymal stem cells (BM-MSCs) and adipose mesenchymal stem cells (AD-MSCs) in the treatment of acetic acid-induced colitis in rats compared to dexamethasone (Dex). Rats were randomly divided into five groups: (1) Control, (2) Acetic acid treated (2 ml of 3% of acetic acid solution, intra-rectally as a single dose), (3) BM-MSCs treated (single i.p. administration of 1{u00D7}106 cells / rat, 24 hours afteracetic acid exposure), (4) AD-MSCs treated (single i.p. administration of 1{u00D7}106 cells/ rat, 24 hours afteracetic acid exposure), and (5) Dex treated (0.5 mg/kg/ for 7 days, i.p.,1 hour after acetic acid exposure).Then all rats were decapitated after 15 days from colitis induction. Acetic acid induced colitis was marked by elevation of edema, myeloperoxidase, malondialdehyde, interleukin-6, interleukin-1Ý, tumor necrosis factor-alpha, caspase-3, fibrosis as well as inflammation together with the reduction of super oxide dismutase, total antioxidant and interleukin-10. These deleterious effects were improved significantly after administration of either BM-MSCs or AD-MSCs. In conclusion, BM-MSCs and AD-MSCs possessed anti-oxidant, anti-inflammatory, anti-apoptotic and anti-fibrotic activity which will probably introduce them as notable candidates for the treatment of colitis