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Abstract Background: Restoring masticatory function and replacing missing teeth with minimal pain and discomfort are the most important issues for the patient and clinician. Nowadays dental implants became the most popular line of treatment to replace missing teeth; offering a comfortable long lasting prosthesis. Osseo-integration reflects the long term success of dental implant. Many bio-modulators are used aiming to improve the osseo-integration and healing around dental implants such as Low Level Laser treatment (LLLT) and Platelet Rich Fibrin (PRF). PRF has been proven to improve bone repair process around dental implant. LLLT is considered a noninvasive, safe technique that stimulates osteogenesis and alleviate post-operative pain. Aim: The aim of current study is to evaluate the bio-stimulatory effect of LLLT on dental implant with PRF compared to PRF alone clinically and radiographically METHODS: we entered nine patients each received two implants in a split mouth design. A total number of eighteen implants were placed in posterior mandibular region. Autologous PRF was prepared for each site and placed during implant placement on both sides and gallium-aluminum-arsenide (GaAlAs) diode low-level laser with continuous emission of 830-nm wavelength was used. The application of laser was performed in eight visits twice weekly from the day of insertion and ended one month after insertion. Data were analyzed using SPSS v.21 software package |