الفهرس 
Title: Correlation between single nucleotide polymorphisms in base excision repair mechanism and HCV associated hepatocellular carcinoma
AbstractOnly 14 pages are availabe for public view
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Abstract
Base-excision repair genes have a vital role in maintaining the genetic stability of the mammalian cells by repairing DNA damages generated by different factors. However, polymorphisms in these genes could affect the enzyme’s activity and may lead to several types of cancer including hepatocellular carcinoma (HCC). Therefore, in the current study, we aimed to determine the possible association between polymorphisms of DNA repair genes, including X-Ray Repair Cross-Complementing group 1 (XRCC1) Arg194Tryp, Arg280His, and Arg399Glu, APE1 Asp148Glu, and NEIL2 Arg257Leu, and the risk of developing hepatitis C virus (HCV)-related HCC. A total of 264 subjects were recruited in this case-control study and were categorized into four groups: 88 control subjects (CR), 53 chronic hepatitis C patients (CHC), 36 liver cirrhotic patients (LC), and 87 HCC patients. The XRCC1 Arg194Tryp, Arg280His, and Arg399Glu polymorphisms were detected using Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), while real-time PCR was used to genotype APE1 Asp148Glu and NEIL2 Arg257Leu. Our data revealed that, compared with the healthy controls, for those subjects with the XRCC1 Arg194Trp genotype, the risk of developing CHC, LC, and HCC was increased by 6.66- (odds ratio (OR)=6.667; 95% confidence interval (CI)=3.244-13.701; P>0.01), 3.85- (OR=3.852; 95% CI=1.797-8.256; P>0.01), and 2.14-fold (OR=2.14; 95% CI=1.13-4.06; P>0.05), respectively