الفهرس 
Expression of tumor necrosis factor alpha-induced protein 3 gene in patients with pPsoriasis vulgaris
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Abstract
Psoriasis vulgaris is a systemic, immune-mediated disorder characterized by inflammatory skin manifestations. Tumor necrosis factor alpha-induced protein 3 (TNFAIP3) has been described as a protective molecule against harmful side effects of uncontrolled inflammation. A strong association between this molecule and psoriasis vulgaris has been reported. The aim of this study was to compare the expression levels of TNFAIP3 gene in blood and psoriatic skin biopsies from psoriatic patients versus those in normal individuals. In addition, the levels of TNFAIP3 protein in psoriatic skin biopsies from patients were compared to those in normal individuals. Thirty psoriatic patients and thirty healthy participants (control group) were enrolled in the study. The expression levels of TNFAIP3 in blood and skin samples were measured by quantitative reverse transcription PCR and the skin levels of TNFAIP3 protein were measured by western blot technique. Psoriatic patients showed significantly lower levels of TNFAIP3 gene expression in psoriatic skin and blood (P < 0.001) as well as of TNFAIP3 protein in psoriatic skin lesions (P < 0.001) compared to the controls