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Abstract Purpose: To evaluate the change in the peripapillary blood flow in primary open-angle glaucoma (POAG) after administration of Dorzolamide 2%/ Timolol 0.5% fixed combination versus Latanoprost 0.005%/Timolol 0.5% fixed combination, using spectral-domain optical coherence tomography (SD-OCT) angiography. Patients and methods: In this prospective comparative non-randomized study, patients with POAG received simultaneous treatment with Dorzolamide 2%/ Timolol 0.5% fixed combination in the right eye and Latanoprost 0.005%/Timolol 0.5% fixed combination in the left eye. Results: group 1 (Dorzolamide 2%/ Timolol 0.5%) showed IOP reduction by 18.9%, one weeks following treatment. group 2 (Latanoprost 0.005%/Timolol 0.5%) Showed IOP reduction by 24.01%. Conclusion: The percentage of IOP reduction was statistically significantly between both Groups. There is an increase in RPC density following treatment in both groups, however this is increase was not statistically significant |