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العنوان
Histopathological evaluation of fetuses of rats treated with anti-emetic domperidone during pregnancy /
الناشر
Doha Hanafy Mahmoud ,
المؤلف
Doha Hanafy Mahmoud
هيئة الاعداد
باحث / Doha Hanafy Mahmoud
مشرف / Rashika Hussin Mostafa
مشرف / Heba Ali Abdelrahman
مشرف / Hamed M.O. Fayed
تاريخ النشر
2018
عدد الصفحات
113 P. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
البيطري
تاريخ الإجازة
13/3/2018
مكان الإجازة
جامعة القاهرة - كلية العلوم - Zoology
الفهرس
Only 14 pages are availabe for public view

from 152

from 152

Abstract

Drugs play an important role in improving human health and promoting well-being.The state of pregnancy requires that all medications should be prescribed with specific caution. Nausea and vomiting are the most common symptoms of pregnancy. Nausea and vomiting of pregnancy (NVP) affects up to 85% of all pregnancies. Treatment of NVP included several routes one of them was antiemetic medication (domperidone). In this study we aimed to investigate the potential effect of domperidone on the pregnancy outcomes and embryos.The study was done using pregnant albino rats (Rattus norvegicus) which treated during organogenesis period with therapeutic dose of the chosen drug. At 20th gestational day all the animals were sacrificed under anesthesia and fetuses with their placentas were removed from the uterus and evaluated for mortality rate, growth parameters,morphological and skeletal malformation also histological study of placenta, fetal liver, kidney and brain.The results revealed a significant decrease in the all growth parameters, high incidence of resorption in treated animals