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Abstract To evaluate the role of CEDM in detection, characterization and diagnosis of axillary lymphadenopathy in patients with breast lesions. Patients and methods: The study included 31 pathological axillary lymph nodes in 28 patients with breast lesions, their age ranged from 28-65 years (mean age 45±9.11 SD). All patients underwent digital mammography, breast ultrasound and CEDM, and all the pathological axillary lymph nodes were examined histopathologically to determine the nature of the lymphadenopathy either benign or malignant. We determined the BIRADS category of each lesion according to the BIRADS atlas 2013, guided by the results of clinical data and the imaging findings but blind to final pathologic diagnosis. Results: All axillary LNs were evaluated regarding the morphological criteria: The cortical thickness (focal or diffuse thickening) and the fatty hila (eccentric or effaced) and also regarding the degree of contrast enhancement either strong, medium, faint or no enhancement. We assessed the sensitivity, specificity, PPV,NPV, total observed accuracy and p-value for both morphological criteria and contrast enhancement characterization of the pathological axillary LNs.We found that the senitivty and specifity of diffuse cortical thickening, effaced fatty hilum, strong contrast enhancement and medium{u2013}strong contrast enhancement for diagnosis of malignant axillary LN were (95.8 %,28.6%), (87.5%,71.4%), 29.2%,100% and 79.2%,57.1% respectively |